Affiliation:
1. Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), 19
Knowledge Park II, Uttar Pradesh 201308, India
Abstract
Abstract:
Quinoline is one of the promising and prominent biologically active N-based heterocyclic
compounds.
:
This review paper aims to discuss the synthetic approaches, summarized from various research articles
on the preparation of quinoline derivatives intended for different therapeutic activities like antifungal
activity, anticancer activity, anticonvulsant activity, antitubercular activity, antimalarial activity,
anti-Alzheimer activity and so on.
:
The comprehensive study complies with all related publications and trademark publications demonstrating
the synthesis and biological aspects of quinoline derivatives.
:
Various types of quinoline hybrids were synthesized and treated for therapeutic activity, including
anticancer, antitubercular, anti-Alzheimer, antioxidant, and antifungal activity, which have been
analyzed.
:
Quinoline is a planner hetero-aromatic compound with the chemical formula C9H7N. Several wellknown
synthetic routes to the quinoline skeleton include Friedlander synthesis, Knorr quinoline synthesis,
and Skraup reaction. Researchers may use other techniques or alter current strategies to reach
their objectives, depending on what exact structure and therapeutic action they are investigating. The
availability of starting materials, reaction conditions, scalability, desired regioselectivity, and functionalization
of the quinoline core all have a role in the choice of synthetic method. This review covers
the latest literature and knowledge on the synthetic procedures for numerous quinoline and its
derivatives and their biological and pharmacological application.
Publisher
Bentham Science Publishers Ltd.