Utilizing NCP@PO(OH)2 as a Core-Shell Magnetic Nano-Catalyst for the Conversion of β-Hydroxy Nitrile to α,β-Unsaturated Carboxylic Acid

Abstract

Abstract: The synthesis of α,β-unsaturated compounds is crucial in organic chemistry, especially in drug discovery and pharmaceutical development. In this study, NCP@POCl2-x (Fe3O4@SiO2@ chitosan@POCl2-x) has been introduced as a new, environmentally friendly, and highly efficient heterogeneous magnetic nanocatalyst for the synthesis of α,β-unsaturated carboxylic acids. This catalyst facilitates the in situ transformation of POCl2-x to PO(OH)2 in the presence of water, effectively converting β-hydroxy nitriles into α,β-unsaturated carboxylic acids through a specific mechanism involving water and heat. The reactions display notable regioselectivity, leading to high-purity products and quantitative yields. NCP@PO(OH)2 exhibits heterogeneity, magnetic properties, straightforward recovery, and outstanding performance, making it a valuable catalyst for efficient and selective transformations of β-hydroxy nitriles. Additionally, it can be easily separated from the mixture of reactions using external magnetic forces.