Affiliation:
1. Key State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of Chemistry, Xinjiang
University, Urumqi, 830017, PR China
Abstract
Abstract:
In this study, a simple one-pot synthesis of acetamides from aromatic amines and acetonitrile
in the presence of H2O and K2S2O8 is presented. The reaction proceeds in a mixed solvent
(CH3CN: DMSO, 3:1) without using metals or toxic reagents. Various N-acetanilides are obtained
with 53-91% yields. The method is selective for aromatic amines, with aliphatic amines remaining intact.
This represents a new, efficient, and economical method for the synthesis of a range of acetamides.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry