Uncatalyzed Synthesis of Unsymmetrical Indole-substituted Methane Derivatives via One-pot Multicomponent Reactions under Solvent-free Conditions

Abstract

For the first time, one-pot multi-component reactions containing indole, aromatic aldehydes, and dimedone have been achieved in the absence of any catalyst under solvent-free conditions. A class of unsymmetrical indole-substituted methane derivatives and symmetrical diindolylmethanes have been synthesized through this green organic synthetic method. Based on experimental results, a reasonable mechanism for this condensation is emphasized here.