Affiliation:
1. Department of Chemistry, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi 75300, Pakistan
2. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Abstract
For several decades, biotransformational studies on steroidal compounds have
gained a lot of attention because it is an efficient approach for the structural modification of
complicated natural or synthetic compounds with high regio-, chemo- and stereoselectivity at
environmentally friendly conditions. This review summarizes the use of different strains of
Cunninghamella blakesleeana for the biotransformation of sixteen steroids 1-16 into a variety
of transformed products. The transformed products may be important as a drug or precursor for
the production of important pharmaceuticals. The types of reactions performed by C.
blakesleeana include hydroxylation, epoxidation, reduction, demethylation, oxidation, glycosidation,
double bond formation, side-chain degradation, isomerisation and opening of an isoxazol
ring, which would be difficult to produce by traditional synthesis.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献