Affiliation:
1. School of Pharmacy, Yantai University, Yantai, 264005, China
2. Institute of Medicinal Biotechnology, Chinese Academy
of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
Abstract
Abstract:
A new phenol derivative, 3-butyryl-2,6-dihydroxy-4-methoxyphenethyl acetate (1) and
seven known phenol analogs (2-8) have been isolated from Arctic fungus Phoma muscivora CPCC
401424. Their structures were elucidated by means of extensive spectroscopic analyses (HRMS,
NMR, and IR), and comparison with reported data. All compounds were obtained from Phoma muscivora
CPCC 401424 for the first time. Compounds 1 and 5 displayed excellent anti-influenza A virus
activities with IC50 values of 2.20 and 2.17 μM, respectively. Compounds 1, 2, 5, and 7 showed moderate
cytotoxic activities against Hela and H460 cancer cell lines.
Funder
National Natural Science Foundation of China
CAMS Innovation Fund for Medical Sciences
National Microbial Resource Center
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry