Affiliation:
1. Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh,
India
Abstract
Abstract:
Advancement in nanotechnology leads to the development of polysaccharides which are
very efficient carriers in delivering therapeutic substances like drugs, proteins, and genes. This review
describes the role of polysaccharides and their derivatives in the cellular targeting of genetic materials
for the treatment of various biological disorders. Applications, challenges, advantages, and disadvantages
of polysaccharides used in gene delivery are discussed in the manuscript. Cationic and natural
polysaccharides are generally used for RNA and DNA delivery and exhibit better performance in gene
transfection. After a substantial literature survey, it can be concluded that different polysaccharides and
their derivatives are effectively used in the delivery of genetic material. Natural polysaccharides are
widely used due to their advantageous properties like biocompatibility, biodegradability, and low toxicity
in the biological environment.
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
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