Affiliation:
1. Pranveer Singh Institute of Technology (Pharmacy), Kalpi Road, Kanpur, India
Abstract
Purpose:
The goal of the present research was to isolate a biopolymer from Phaseolus vulgaris
(P. vulgaris) and Zea mays (Z. mays) plants and used it to construct Resveratrol (RES)-loaded
translabial films.
Methods:
Biopolymers were extracted from P. vulgaris and Z. mays seeds using a simple process. Separated
biopolymers, sodium carboxymethylcellulose (SCMC) and tragacanth were subjected to formulation
development by incorporating RES-loaded translabial films. The Fourier-transform infrared spectroscopy
(FTIR), physical appearance, weight, thickness, folding endurance, swelling index, surface
pH, percent moisture absorption, percent moisture loss, vapor transfer rate, and content uniformity of
the translabial films were examined. The mucoadhesive, ex-vivo permeation, in vivo and stability studies,
were performed.
Results:
The results showed that RES-loaded translabial films produced from P. vulgaris and Z. mays
biopolymers exhibited exceptional mucoadhesive, stability, and permeation properties. Results revealed
that the best formulations were prepared from a combination of biopolymer (P. vulgaris C or Z. mays
C) with tragacanth. Formulations with tragacanth revealed good swelling and thus permeation profiles.
In vivo release of TL 11 was found to be 24.05 ng/ml in 10 hours and it was stable enough at 45oC.
Conclusion:
This research suggested that RES-loaded translabial formulations can be potentially used
for the treatment of Parkinson’s disease with good patient compliance to geriatric and unconscious patients.
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
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