Affiliation:
1. Division of Perfume
and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, People’s Republic of China;
2. Collaborative Innovation
Center of Fragrance Flavour and Cosmetics, Shanghai 201418, People’s Republic of China
3. Bloomage Biotechnology Corporation Limited, Shanghai 200131, People’s Republic of China
4. Division of Perfume
and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, People’s Republic of China
Abstract
Aim:
The aim of this study was to encapsulate glabridin (GB) into nanoparticles, prepared by
an ionic-gelation method blended with chitosan (CS) and poly-γ-glutamic acid (γ-PGA) to address the
issue of poor stability and low water solubility of glabridin.
Methods:
The physicochemical properties of nanoparticles were investigated by transmission electron
microscope (TEM), dynamic light scattering (DLS) and fourier-transform infrared (FT-IR) spectroscopy.
Result:
FT-IR results indicated that the spontaneous interaction between CS, γ-PGA and GB can form
a cross linked network-structure, leading to the spontaneous formation of nanoparticles. Morphology of
the complex particles was nano-scale spherical shape. Furthermore, particle size was decreased according
to the decrease of γ-PGA contents and CS, accompanying with the increase of mixed solution
transmittance. The mγ-PGA: mGB = 1: 1 and mCS: (mγ-PGA + mGB) =1: 1 were considered to be a proper
preparation condition of CS/γ-PGA/GB hybrid nanoparticles, which produced the smaller nanoparticles
with the satisfactory encapsulation efficiency (EE), loading content (LC) and sustained GB release.
With the increase of pH values, the potential, EE, and LC decreased gradually, while the particle size
increased. The nanoparticles prepared with higher molecular weight γ-PGA had larger particle size and
less loading capacity on GB. Additionally, moderate weight ratio of CS/γ-PGA/GB, low pH, and high
molecular weight of γ-PGA were favorable for sustained release.
Conclusion:
It can be concluded that the physicochemical properties of nanoparticles and GB release
behaviors were affected by several factors including the weight ratio of CS/γ-PGA/GB, pHvalues, and
γ-PGA molecular weight (MW). Nanoencapsulation using CS, γ-PGA and GB has a potential application
for the development of functional cosmetic products with skin-whitening effect.
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
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