Development and Challenges of Synthetic Retinoid Formulations in Cancer-Reference-Cited by-同舟云学术

Development and Challenges of Synthetic Retinoid Formulations in Cancer

Published:2023-11 Issue:9 Volume:20 Page:1314-1326
ISSN:1567-2018
Container-title:Current Drug Delivery
language:en
Short-container-title:CDD

Author:

Saad Walid¹,Darwiche Nadine²^ORCID,Assi Sara³,Hajj Hiba El⁴,Hayar Berthe²,Pisano Claudio⁵^ORCID

Affiliation:

1. Department of Chemical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon

2. Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

3. Department of Biomedical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon

4. Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

5. Biogem, Institute of Molecular Biology and Genetics, via Camporeale, 83031 Ariano Irpino(AV), Italy

Abstract

Abstract: Retinoids represent a class of chemical compounds derived from or structurally and functionally related to vitamin A. Retinoids play crucial roles in regulating a range of crucial biological processes spanning embryonic development to adult life. These include regulation of cell proliferation, differentiation, and cell death. Due to their promising characteristics, retinoids emerged as potent anti-cancer agents, and their effects were validated in vitro and in vivo preclinical models of several solid and hematological malignancies. However, their clinical translation remained limited due to poor water solubility, photosensitivity, short half-life, and toxicity. The development of retinoid delivery formulations was extensively studied to overcome these limitations. This review will summarize some preclinical and commercial synthetic retinoids in cancer and discuss their different delivery systems.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmaceutical Science

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