Affiliation:
1. Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Background:
Metformin Hydrochloride (MH) is an oral anti-hyperglycemic agent belonging
to the biguanide class of drugs.
Objective:
The present study involves the formulation and evaluation of gastro-retentive floating
microparticles containing MH as a model drug for the prolongation of absorption time.
Methods:
Three levels of a three-factor, Box-Behnken design were used to evaluate the critical formulation variables.
Microparticles were prepared using a water-in-oil-in-water double-emulsion solvent evaporation method and examined in
terms of production yield, particle size, entrapment efficiency, floating ability, morphology, FTIR (Fourier transform
infrared spectroscopy), and in vitro drug release.
Results:
The optimum conditions for preparing MH microparticles were predicted to be the content
of ethyl cellulose content (150 mg),poly (ε-caprolactone) (150 mg), and polyvinyl alcohol
(1%w/v).The optimized MH microparticles were found to be spherical with a mean size of 350.2
μm. Entrapment efficiency was 58.62% for microparticles. 63.94% of microparticles showed floating
properties. The FTIR analysis confirmed no chemical linkage between microparticle components.
in vitro release study showed a controlled release for up to 8h.
Conclusion:
These results demonstrated that MH microparticles, as a drug delivery system, may
be useful to achieve a controlled drug release profile suitable for oral administration and may help
to reduce the dose of the drug and to improve patient compliance.
Funder
Iran National Science Foundation
Faculty of Pharmacy at Tabriz University of Medical Sciences
Publisher
Bentham Science Publishers Ltd.
Cited by
8 articles.
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