Affiliation:
1. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144402, India
Abstract
Abstract:
One of the most frequent malignancies in the world is colon cancer. Both men and women
are affected in the same way. The colon, which makes up the last part of the digestive system and is
where water and minerals from food waste are absorbed, is vulnerable to cancer. The most suitable
technique of drug administration is oral administration. Aqueous solubility is low in more than 40% of
novel chemical entities, resulting in poor oral drug administration. In the formulation of oral medications,
low inconsistent bioavailability is a major challenge. Increasing medication bioavailability is one
of the most difficult aspects of pharmacological development. Self-nano-emulsifying drug delivery systems
(SNEDDS) have been a potential platform for biopharmaceutical classification system class II and
IV drugs for oral delivery. Enhanced bioavailability and solubility, control of toxicity, pharmacological
effects, improved stability, improved tissue macrophage dispersion, prolonged delivery, and resistance
to physical and chemical degradation are just a few benefits of SNEDDS for herbal drugs. To increase
activity and address problems associated with herbal drugs, nanosized modern drug delivery technologies
are expected to have a promising future. Improved patient compliance, fewer problems with liquid
SNEDDS filled in capsules, and enhanced stability SNEDDS are all benefits of converting liquid
SNEDDS to solid oral dosage forms or solid SNEDDS. SNEDDS differs from previous solubility augmentation
methods due to its biodegradable components, simplicity of large-scale production, and range
of drug-targeting possibilities.
Publisher
Bentham Science Publishers Ltd.