Therapeutic Approaches of Dual-targeted Nanomedicines for Tumor Multidrug Resistance

Author:

Han Weili1,Shen Zhenglin2,Zou Jie2,Ye Qiufang2,Ge Cheng2,Zhao Yuqin2,Wang Ting2,Chen Yafang2

Affiliation:

1. Department of Pharmacy, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, PR China.

2. Department of Pharmacy, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, PR China

Abstract

Abstract: Currently, the main cause of cancer chemotherapy failure is multi-drug resistance (MDR), which involves a variety of complex mechanisms. Compared with traditional small-molecule chemotherapy, targeted nanomedicines offer promising alternative strategies as an emerging form of therapy, especially active targeted nanomedicines. However, although single-targeted nanomedicines have made some progress in tumor therapy, the complexity of tumor microenvironment and tumor heterogeneity limits their efficacy. Dual-targeted nanomedicines can simultaneously target two tumor-specific factors that cause tumor MDR, which have the potential in overcoming tumor MDR superior to single-targeted nanomedicines by further enhancing cell uptake and cytotoxicity in new forms, as well as the effectiveness of tumor-targeted delivery. This review discusses tumor MDR mechanisms and the latest achievements applied to dual-targeted nanomedicines in tumor MDR.

Funder

Natural Science Foundation of Jiangsu Province

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmaceutical Science

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