Affiliation:
1. Department of Pharmaceutics, SRM College of Pharmacy, SRM University, Kattankulathur, Chennai, India
2. Department of Pharmacology, KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, KL deemed to be
University, Vaddeswaram, Andhra Pradesh, India
Abstract
Abstract:
Nature contains a diverse range of phytoconstituents that possess several pharmacological
properties. However, the effectiveness of herbal formulations is limited due to the poor bioavailability
of phytoconstituents, which makes it difficult for them to pass through the cell membrane.
Phytosomes are a modern type of herbal formulation that comprises therapeutically active
phytoconstituents extracted from medicinal plants and enclosed by phospholipids. By combining
phytoconstituents with phospholipids, phytosomes are able to enhance bioavailability and reduce
side effects. Various techniques such as solvent evaporation, rotatory evaporation, anti-solvent precipitation,
freeze-drying, and solvent ether injection can be used to prepare phytosomes. Phytosomes
can be evaluated using methods such as UV-Spectra, DSC, drug entrapment and loading capacity,
surface tension activity measurement, and in-vitro/in-vivo studies. This review discusses
different methods for preparing phytosomal formulations and their advantages, which have been
found to significantly improve the bioavailability of phytoconstituents. Phytosomes have high entrapment
efficiency and do not compromise the safety of nutrients. By utilizing phytosomal drug
delivery, issues associated with conventional drug delivery may be overcome. Therefore, it is important
to combine Indian Ayurvedic medicine with novel drug delivery systems to improve drug
delivery technologies.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
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