Affiliation:
1. Department of Clinical Ophthalmology, University College London (UCL), London, United Kingdom
Abstract
Abstract:
Age-related macular degeneration (ARMD or AMD) is a progressive, sight-threatening
disease. The pathogenesis of ARMD is complex, involving many factors, such as metabolic, functional,
genetic, and environmental factors. Recently, long interspersed nuclear element-1 (L1)–
mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
(cDNA) has been associated with retinal pigment epithelium (RPE) destruction. These findings
provide a strong input for a new direction in the management of ARMD, as certain human immunodeficiency
virus (HIV) drugs, such as nucleoside reverse transcriptase inhibitors (NRTIs), were
found to suppress inflammation and protect cells of the retina.
Publisher
Bentham Science Publishers Ltd.
Subject
Geriatrics and Gerontology,Aging