Affiliation:
1. Traslational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico
2. Obesity and Digestive Diseases
Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico
Abstract
Abstract:
Metabolically associated fatty liver disease, formerly called nonalcoholic fatty liver disease,
is the most common liver disease globally, representing the third cause of liver transplantation.
Metabolically associated fatty liver disease is defined as having more than 5% lipid droplets in
hepatocytes without other concomitant liver diseases. Various stimuli such as the secretion of inflammatory
cytokines, mitochondrial and endoplasmic reticulum dysfunction due to oxidative stress, alteration
of the intestine-liver axis, bacterial dysbiosis, as well as genetic and epigenetic factors can modify
the progression of metabolically associated fatty liver disease to fibrosis, cirrhosis, and may reach
hepatocellular carcinoma. Epigenetics is responsible for a highly sophisticated regulatory system that
controls many cellular processes in response to multiple environmental factors as an adaptive mechanism
unrelated to alterations in the primary deoxyribonucleic acid sequence, including gene expression,
microRNAs, DNA methylation, modifications in histones, and DNA-protein interactions. Several
studies have shown that epigenetic changes are associated with various diseases, including metabolically
associated fatty liver disease. Nutri epigenomics is the interaction between nutrition and components
at the transcriptional or post-transcriptional level. Methylation processes involve micronutrients
that regulate epigenetic states in a physiological and pathological context. Micronutrients such as
methionine, folate, and choline are the main components of one-carbon metabolism, functioning as
methyl group donors, and their deficiency predisposes to various pathologies such as metabolically
associated fatty liver disease. Understanding of epigenetic modifiers leads us to develop new therapeutic
therapies for patients with metabolically associated fatty liver disease.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine