A Short Review of Antimalarial Compounds with Sulfonamide Moiety-Reference-Cited by-同舟云学术

A Short Review of Antimalarial Compounds with Sulfonamide Moiety

Published:2023-11 Issue:21 Volume:23 Page:2073-2088
ISSN:1389-5575
Container-title:Mini-Reviews in Medicinal Chemistry
language:en
Short-container-title:MRMC

Author:

Dantas Leonardo C.¹,Campos Vinicius R.¹^ORCID,Borges Julio C.²,Pinheiro Luiz C.S.³^ORCID

Affiliation:

1. Departamento de Química Orgânica, Programa de Pós-Graduação em Química, Universidade Federal Fluminense- UFF, Instituto de Química, Niterói, RJ, Brazil

2. Department de Quimica, Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro-IFRJ Campus Nilópolis, RJ, Brazil

3. Departamento de Ciências Faculdade de Formação de Professores, Universidade do Estado do Rio de Janeiro - UERJ, São Gonçalo, RJ, Brazil

Abstract

Abstract: Malaria is a public health problem that causes thousands of deaths, primarily in children in African regions. Artemisinin-based combination therapies (ACTs) have helped to save thousands of lives; however, due to Plasmodium's resistance to available treatments, there is a need to search for new low-cost drugs that act through different mechanisms of action to contain this disease. This review shows that compounds with sulfonamide moiety, possibly, act as inhibitors of P. falciparum carbonic anhydrases, moreover, when linked to a variety of heterocycles potentiate the activities of these compounds and may be used in the design of new antimalarial drugs.

Funder

Foundation for Research of the State of Rio de Janeiro

Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior - Brasil

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

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