Affiliation:
1. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India
2. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati,
Changsari, Kamrup, Assam, 781101, India
Abstract
Abstract:
Flavonoids are natural polyphenolic compounds and constitute a major class of plant secondary
metabolites. To date, structures of more than 10,000 different flavonoids have been elucidated,
and most of them are present in cells and tissues of plant parts. Flavonoids have been reported to exert
multiple physiological activities and are also consumed as dietary supplements. Flavonoids have been
extensively explored as anticancer, anti-inflammatory, antidiabetic, antirheumatic, antioxidant, antimalarial,
neuroprotective, cardioprotective, anti-angiogenic, and antiproliferative agents. Most of the
flavonoids are biosynthesized in plants via the phenylpropanoid pathway. However, they are associated
with some limitations. Chemical synthesis is an alternative strategy to improve the yield and obtain
purified products but is hampered by drawbacks, such as intolerance to stressful lab conditions. Pharmacokinetics
is the rate-limiting step defining the bioavailability and metabolism of flavonoids, though
greatly influenced by their chemical structure. However, nanoformulation is an emerging technique
to improve biopharmaceutical fate and achieve target drug delivery. Thus, much attention should be
given to identifying other possible chemical approaches for synthesizing flavonoids and improving
their pharmacokinetic profiling, hence potentiating their efficacy in clinic.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
4 articles.
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