Selection of Suitable Protein Structure from Protein Data Bank: An Important Step in Structure-based Drug Design Studies-Reference-Cited by-同舟云学术

Selection of Suitable Protein Structure from Protein Data Bank: An Important Step in Structure-based Drug Design Studies

Published:2023-02 Issue:3 Volume:23 Page:246-264
ISSN:1389-5575
Container-title:Mini-Reviews in Medicinal Chemistry
language:en
Short-container-title:MRMC

Author:

Yadav Mange Ram¹,Murumkar Prashant R.²^ORCID,Sharma Mayank Kumar²,Gupta Pradeep³,Patel Niyati M.²

Affiliation:

1. Centre of Research for Development, Parul University, Limbda, Vadodara- 391760, India

2. Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara - 390001, India

3. Mankind Pharma Ltd, Gurugram, Haryana 122050, India

Abstract

Abstract: Selection of a protein structure is an important step for the success of the drug discovery process using structure-based design. Selection of the right crystal structure is a critical step as multiple crystal structures are available for the same protein in the protein data bank (PDB). In this communication, we have discussed a systematic approach for selecting the right type of protein structure. Some case studies for the selection of crystal structures of TACE, 11β-HSD1, DprE1 andSARS-CoV-2 Mpro enzymes have been discussed for the purpose of illustration.

Funder

AICTE, Research Promotion Scheme, India

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

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