Affiliation:
1. Department of Chemistry, Military Institute of Engineering, Rio de Janeiro, Brazil
Abstract
Over the years, the development of bioactive heterocycles has aroused the interest of the
scientific community, because in general, these heterocycles are strategic in maintaining life. Research
into bioactive heterocycles is associated with the development of methods of synthesis and the biological
evaluation of different nuclei. In consequence, there has been a growing interest in the nucleus of
fused pyrimidine, which has diversified pharmacological activities, including diuretic, antimicrobial,
antifolate, tyrosine kinase, anti-inflammatory, anticancer, anthelminthic, and antiviral activities. This
review focuses on describing a diverse set of structures derived from pyrimido[4,5-d]pyrimidines and
contemplates the main bioactivities of these nuclei.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献