Affiliation:
1. Chemistry of Heterocycles & Natural Product Research Laboratory, Department of Chemistry, School of Advanced
Sciences, Vellore Institute of Technology, Vellore – 632014, Tamil Nadu, India
2. Department of Chemistry, School of
Advanced Sciences, Vellore Institute of Technology, Vellore – 632014, Tamil Nadu, India
Abstract
Abstract:
The wide pharmaceutical activity of the bioactive heterocycles, which include nitrogen,
oxygen, and sulphur and comprise five- and six-membered rings, has drawn the attention of medicinal
chemists for several years. The therapeutic potential of bioactive heterocycles for a variety of disorders
lies in their medicinal effects. The most prominent of them is Alzheimer's disease (AD), a
neurodegenerative disorder that impairs memory and causes other psychiatric problems. Globally, there
are around 54 million cases, and by 2050, that number is predicted to rise by 131 million. So far,
donepezil, galantamine, and rivastigmine have indeed received FDA approval for use in the treatment of
AD. In this regard, the pharmacophoric properties of heterocycle molecules are equivalent to those of
galantamine mimics. Therefore, it is beneficial to create novel compounds containing these moieties and
test their ability to inhibit acetyl and butyl cholinesterase. Diverse heterocyclic scaffolds may now have
therapeutic potential for Alzheimer's disease. Recently, greener and more expeditious synthesis of
bioactive heterocycles has drawn much attention because of the utilisation of environmentally benign
protocols, thereby diminishing the usage of hazardous chemicals. In this review, we discuss the most
pertinent findings about the "green" synthesis of heterocycles and their possible anti-activity against
Alzheimer's.
Publisher
Bentham Science Publishers Ltd.
Cited by
2 articles.
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