Affiliation:
1. Departamento de Química Orgânica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro,
Brazil
Abstract
Abstract:
Chloroarenes are important from both academic and industrial points of view. They are useful
intermediates and building blocks in manufacturing a range of bulk and fine aromatic chemicals, dyes,
flame retardants in electronic boards, disinfectants, and pharmaceutical drugs. In addition, diverse agrochemicals, synthetic drugs, and natural products are chloroarenes. Although conventional chlorination of
arenes is a well-established transformation that has been studied in detail in many textbooks, current challenges
have driven scientists to design new strategies that can address the need for efficiency and sustainability. The
oxidative chlorination reaction proceeds via an oxidation step of the chloride ion to generate the active
electrophilic chlorenium species in situ. In these regards, the present review focused on the main
achievementsof the oxidative chlorination of arenes, with special focus on their generality and green aspects. Therefore, the use of different oxidants (hydrogen peroxide, oxygen, iodine(III) reagents, enzymes)
and conditions of electrochemistry and photocatalysis are presented.
Publisher
Bentham Science Publishers Ltd.