Affiliation:
1. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh - 786004, Assam, India
2. Faculty of Pharmaceutical
Sciences, Assam Down Town University, Panikhaiti, Guwahati-781026, Assam, India
Abstract
Background:
Cancer-induced mortality is increasingly prevalent globally, which skyrocketed
the necessity to discover new/novel, safe and effective anticancer drugs. Cancer is characterized
by the continuous multiplication of cells in the human, which is unable to control. Scientific research
is drawing its attention toward naturally-derived bioactive compounds as they have fewer side effects
compared to the current synthetic drugs used for chemotherapy.
Objective:
Drugs isolated from natural sources and their role in the manipulation of epigenetic markers
in cancer are discussed briefly in this review article.
Methods:
With advancing medicinal plant biotechnology and microbiology in the past century, several
anticancer phytomedicines were developed. Modern pharmacopeia contains at least 25% herbal-based
remedies, including clinically used anticancer drugs. These drugs mainly include the podophyllotoxin
derivatives vinca alkaloids, curcumin, mistletoe plant extracts, taxanes, camptothecin, combretastatin,
and colchicine artesunate, homoharringtonine, ellipticine, roscovitine, maytansine, tapsigargin,and
bruceantin.
Results:
Compounds (psammaplin, didemnin, dolastin, ecteinascidin, and halichondrin) isolated from
marine sources and animals such as microalgae, cyanobacteria, heterotrophic bacteria, invertebrates.
They have been evaluated for their anticancer activity on cells and experimental animal models and
used chemotherapy.Drug-induced manipulation of epigenetic markers plays an important role in the
treatment of cancer.
Conclusion:
The development of a new drug from isolated bioactive compounds of plant sources has
been a feasible way to lower the toxicity and increase their effectiveness against cancer. Potential anticancer
therapeutic leads obtained from various ethnomedicinal plants, foods, marine, and microorganisms
are showing effective yet realistically safe pharmacological activity. This review will highlight
important plant-based bioactive compounds like curcumin, stilbenes, terpenes, other polyphenolic
phyto-compounds, and structurally related families that are used to prevent/ ameliorate cancer. However,
a contribution from all possible fields of science is still a prerequisite for discovering safe and
effective anticancer drugs.
Funder
All India Council for Technical Education
Indian Council of Medical Research
Publisher
Bentham Science Publishers Ltd.
Cited by
11 articles.
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