Diphenyl Ethers: Isolation, Bioactivities and Biosynthesis

Author:

Liu Bing12,Wang Yuxin1,Chen Ning12,Li Chenxue2,Zhao Jintong1,Li Ting3

Affiliation:

1. Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin, P.R. China

2. National Anti-tumor Natural Drug Engineering Research Center of Ministry of Education of Harbin University of Commerce, Harbin, P.R. China

3. School of International Studies, Harbin Institute of Technology, No.92 Xidazhi Street, Nangang District, Harbin, 150001, P.R. China

Abstract

Abstract: Diphenyl ethers (DPEs) are mainly produced by microorganisms and plants. The chemical structure of DPEs is relatively simple, and all of these compounds have the structure of biphenyl ethers in their chemical structure, the difference being the difference in the substituents on the benzene ring. Several recent studies have shown antibacterial, antioxidant, antitumor, antitumor, antihemolytic, neuroprotective, and anti-Alzheimer effects. DPEs could be candidate compounds for the treatment of Alzheimer's disease, by inhibiting the aggregation of Aβ42. Many DPEs from natural products exhibit good biological activity and they play an important role in the control of microbial infections. Diphenyl ethers have a wide range of applications and research value in the fields of pesticides, pharmaceuticals, textiles, household products, and public health. In this paper, we review the research progress of diphenyl ethers isolated from marine and plant endophytic sources in recent years, including their biosynthesis, and lay the foundation for further utilization and development.

Funder

Outstanding Youth of Heilongjiang Natural Science Foundation

Heilongjiang postdoctoral fund

Young innovative talents training plan of Heilongjiang regular undergraduate colleges and Universities

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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