1-Cyanoacetylthiosemicarbazides: Recent Advances in their Synthesis, Reactivity in Heterocyclization, and Bio-Applications

Author:

Bondock Samir1ORCID,Alabbad Nada1,Hossan Aisha1ORCID,Abdou Moaz M.2

Affiliation:

1. Chemistry Department, Faculty of Science, King Khalid University, Abha, 9004, Saudi Arabia

2. Chemistry Department, Egyptian Petroleum Research Institute, Nasr City, Cairo, 11727, Egypt

Abstract

Abstract: The synthesis of 1-cyanoacetylthiosemicarbazides is at the apex attention of researchers due to their multifaced reactivity as versatile precursors in the synthesis of mono-, bi-, and fused_heterocyclic compounds as well as metal complexes. Despite this, no comprehensive survey was, so far, dedicated to the synthesis, chemical transformation, and bioactivities of this relevant family of synthetic organic precursors and their derivatives. The present survey aims to summarize an up-to-date record of the preparation of 1-cyanoacetylthiosemicarbazides and their chemical transformation. A particular focus is given to their metal complexes and bio-applications

Funder

Deanship of Scientific Research at King Khalid University

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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