Natural Products from Octocorals of the Genus Verrucella (Milne Edwards & Haime, 1857)

Author:

Liaw Chia-Ching1,Sung Ping-Jyun23456,Wu Yu-Jen7,Neoh Choo-Aun8,Tsai Yu-Chi2,Lo Yi-Hao9310,Wu Yang-Chang114,Wen Zhi-Hong312

Affiliation:

1. Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112304, Taiwan

2. National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan

3. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan

4. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404394, Taiwan

5. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807378, Taiwan

6. Ph.D. Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei 242062, Taiwan

7. Department of Food Science and Nutrition, Meiho University, Pingtung 912009, Taiwan

8. Department of Research, Pingtung Christian Hospital, Pingtung 900026, Taiwan

9. Department of Family Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813204, Taiwan

10. Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan

11. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404333, Taiwan

12. Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804201, Taiwan

Abstract

Abstract: In this review, we summarize the diverse marine natural compounds obtained from the genus Verrucella and their pharmacological effects and present a survey of the natural products taxonomy according to species. Sixty-six natural substances, including fifty-three steroids, six briarane-type diterpenoids, five nitrogenous bases, one amide, and one glycerol derivative, were obtained from Verrucella spp., which were mainly collected from the South China Sea and the Bay of Bengal, India. Steroids were the major constituents found in Verrucella spp. Moreover, anticancer, antimicrobial, and immunomodulatory activities of those steroids and other compounds are also presented. This review reveals the chemical diversity, chemotaxonomy, and multiple pharmacological effects of the Verrucella genus. It will be helpful for further research and exploration of new steroid analogs and other components with prospective biological activities from this marine organism.

Funder

Ministry of Science and Technology of Taiwan

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

Reference106 articles.

1. Cordeiro, R.; McFadden, C.; van Ofwegen, L.; Williams, G. World List of Octocorallia. Verrucella (Milne Edwards

2. Cordeiro, R.; McFadden, C.; van Ofwegen, L.; Williams, G. World List of Octocorallia. Gorgonella (Valenciennes, 1855). World Register of Marine Species. Available from: (Accessed May 31, 2021).

3. Sivaleela, G. Padmanaban. Studies on the Alcyonacean fauna of Gulf of Mannar. Rec. Zool. Surv. India, 2015, 115, 21-30. Available from:

4. Subrahmanyam C.; Kulatheeswaran R.; Ward R.S.; Briarane diterpenes from the Indian Ocean gorgonian Gorgonella umbraculum. J Nat Prod 1998,61(9),1120-1122

5. Subrahmanyam C.; Ratnakumar S.; Ward R.S.; Umbraculolides B-D, further briarane diterpenes from the gorgonian Gorgonella umbraculum. Tetrahedron 2000,56,4585-4588

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