Synthesis and Medicinal Applications of Fenamic Acid Derivatives-Reference-Cited by-同舟云学术

Synthesis and Medicinal Applications of Fenamic Acid Derivatives

Published:2023-07 Issue:13 Volume:27 Page:1132-1142
ISSN:1385-2728
Container-title:Current Organic Chemistry
language:en
Short-container-title:COC

Author:

Sharma Mousmee¹,Prasher Parteek²

Affiliation:

1. Department of Chemistry, Uttaranchal University, Dehradun 248007, India

2. Department of Chemistry, University of Petroleum & Energy Studies, Energy Acres, Dehradun 248007, India

Abstract

Abstract: Fenamic acid-derived NSAIDs contain N-phenyl anthranilic acid as a pharmacophore with pKa ~ 4, which is completely ionized at the physiological pH and is mainly excreted in the urine by hydroxylation or glucuronidation. The acid (-COOH) functionality in fenamic acid provides a template for their fenamate derivatization for the development of analogues based on amidation, esterification, and etherification. Besides the repurposing of fenamates as neuroprotective agents in unmodified form, several of their derivatives have been reported for the management of disease pathogenesis by regulating the responsible pathways. In this review, we discuss the chemical modification of fenamic acid and its medicinal chemistry thereof.

Funder

DST-SERB, India

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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