Affiliation:
1. Laboratório de pesquisa em Bioprodutos e Síntese, Universidade Estadual de Goiás, Anápolis, GO, Brazil
2. São Carlos Institute of
Physics, University of São Paulo, São Carlos-SP, Brazil
3. Grupo de Química Teórica e Estrutural de Anápolis, Universidade Estadual
de Goiás, Anápolis, GO, Brazil
Abstract
Abstract:
A review concerning the synthesis and pharmacological properties of pyrazoles
obtained from Chalcone described in the literature over the last 5 years (2016-2020) was presented
and discussed. Among the synthetic approaches for pyrazoles described so far, the
cyclization and acetylation method of α,β-unsaturated chalcones, and substituted hydrazine
were selected and analyzed. 105 pyrazole derivatives (3-107) were evaluated as well as their
pharmacological activities, namely, antineoplastic, anti-inflammatory, antioxidant, antibacterial,
antifungal, antimycobacterial, antiplasmodial, Alzheimer's disease, enzymes inhibition
(like acetylcholinesterase, carbonic anhydrase, and malonyl CoA decarboxylase), anticonvulsant,
among others. Pyrazolic compounds are widely used in the design of the new drug with
a wide spectrum of pharmacological approaches. Therefore, it is relevant to research the synthetic
methods and therapeutic properties of different pyrazole derivatives.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Fundação de Amparo à Pesquisa do Estado de São Paulo
Publisher
Bentham Science Publishers Ltd.
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