Dracaenone, a Novel Type of Homoisoflavone: Natural Source, Biological Activity and Chemical Synthesis

Author:

Lu Jun12,Deng Yun1,Li Mei-Mei1ORCID

Affiliation:

1. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China

2. Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 999077, China

Abstract

Abstract: The discovery and synthesis of natural products, especially those possessing novel scaffolds, are crucial to the development of new drugs. Dracaenones are part of homoisoflavone natural products, owning a complex spiro-bridged polycyclic structure bearing benzylic quaternary carbon centers, and some of them reveal considerable biological activity. There have been continuous studies on these compounds due to the rare structure and important biological properties. However, a systematic summary and analysis for dracaenone is lacking. This review aims to generally summarize the natural source, synthetic strategies and biological activities of dracaenones, moreover, the limitations, challenges, and future prospects were discussed, wishing to provide references for the follow-up study of compounds with similar skeleton.

Funder

National Natural Science Foundation of China

Xinglin Scholar Research Promotion Project of Chengdu University of Traditional Chinese Medicine

China Postdoctoral Science Foundation

Scientific Research Foundation of the Science & Technology Department of Sichuan Province

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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