Affiliation:
1. Chemistry Department, NOVA School of Science & Technology, Universidade Nova de Lisboa Campus de Caparica, 2829-516 Caparica, Portugal
Abstract
:
In the past few years, the number of protocols for α-amination of carbonyl compounds
has dramatically increased, highlighting the importance of this moiety. While some
classical approaches continue to be used, supported by novel catalysts, new methods with
unique advantages have also emerged. Among these, a wide variety of conditions can be observed,
such as the use of umpoled enolates with nucleophilic nitrogen sources, the generation
of electrophilic nitrogen sources, and oxidative methods, generally through the generation of
radical species. This review aims to compile the most recent publications for the α-amination
of carbonyls on the basis of synthetic utility, novel transformations, and enantioselectivity.
Publisher
Bentham Science Publishers Ltd.