Affiliation:
1. Institute of Chemistry,
Vietnam Academy of Science and Technology (VAST), Hanoi, 100000, Vietnam
2. Graduate University of Science and
Technology, VAST, Hanoi, 100000, Vietnam
3. Faculty of Chemistry, Hanoi Pedagogical University 2 (HPU2), Vinhphuc, 15000, Vietnam
Abstract
Background:
Hairy agrimony (Agrimonia pilosa Ledeb.) is a traditional medicinal plant
widely used in Eastern Europe and Eastern Asia. The plant is harvested as it comes into flower and
could be dried for later usage. Hairy agrimony has been traditionally introduced to treat sore throat,
abdominal pain, headache, mucoid dysentery, bloody and white discharge, parasites, and eczema.
Objective:
Since the 1950s, various experimental reports relating to phytochemical and pharmacological
aspects have been observed, but an overview is now not available. The current paper emphasizes
on in-depth information about the botanical description, traditional use, phytochemistry, and
pharmacology.
Methods:
The collection of previous research is basically dependent on the reliable resources Sci-
Finder, Google Scholar, ScienceDirect, reputation publishers, and thesis books.
Results:
A. pilosa was found to contain a variety of chemical classes. To date, more than 160 secondary
metabolites have been separated, and the derivatives type flavonoids, phloroglucinols, tannins,
isocoumarins, and triterpenoids are the main components. A. pilosa crude extracts and their
isolates set a broad panel of pharmacological values, including anti-cancer, anti-microbial, antivirus,
anti-oxidant, anti-inflammation, anti-diabetes, anti-osteosarcoma, anti-aging, anti-nociception,
anti-adipogenesis, anti-leishmaniasis, estrogenic-like activity, neuroprotective and hepatoprotective
activities, and vascular relaxation.
Conclusion:
In vitro and in vivo results also successfully explained the pharmacological mechanisms
of A. pilosa constituents. More bioassay-guided phytochemical and clinical studies are necessary.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Computer Science Applications,Drug Discovery,General Medicine
Cited by
5 articles.
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