Affiliation:
1. College of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun Jilin province, 130118, China
Abstract
Objective:
This study aimed to investigate the therapeutic effect of Specnuezhenide on
myelosuppression induced by chemotherapy and clarify its mechanism.
Methods:
In this study, we measured peripheral blood cells, thymus index, spleen index, bone marrow
nucleated cells (BMNCs), and the number of cell colonies counted in vitro by hematopoietic
progenitor cells (HPCs) to determine the effect of SPN on cyclophosphamide (CTX)-induced myelosuppression.
The alterations in the expression of relevant proteins, the cell cycle, and cytokines
associated with hematopoietic cells were examined to better understand how it works.
Results:
In the cyclophosphamide-induced mouse model, our study discovered that SPN can increase
the number of peripheral blood cells and BMNCs after treatment, increase the thymus index
and decrease the spleen index, and promote the proliferation and differentiation of HPCs. SPN can
improve the production of cultured colonies in vitro, reduce the level of hematopoietic factors in vivo,
regulate the proportion of G0/G1 phase cells, and promote the normal growth and development of
cells. SPN can increase the expression levels of key proteins MEK and p-ERK in the MAPK signaling
pathway, which may be one of the important mechanisms for improving myelosuppression.
Conclusion:
SPN can enhance the hematological and immunological functions of myelosuppressionmice,
and it is hypothesized that SPN is extremely helpful to the hematopoietic and immune
functions of tumor patients following chemotherapy. SPN might be used to treat myelosuppression.
Additionally, high doses of SPN have a stronger therapeutic effect than low levels of SPN.
Funder
National Key R&D Program of China
Jilin Province Science & Technology Development Plan
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Computer Science Applications,Drug Discovery,General Medicine
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