Affiliation:
1. Department of Pharmacy, Hyogo Medical University Hospital, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501,
Japan
2. Department of Respiratory Medicine and Hematology, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya,
Hyogo, 663-8501, Japan
Abstract
Aim:
Weight gain with the use of dolutegravir, bictegravir, and tenofovir alafenamide for
antiretroviral therapy has been reported. However, studies on changes in body composition and the
leptin/adiponectin ratio after antiretroviral therapy initiation are limited. These factors are important
because they can be used as indicators of metabolic syndrome and cardiovascular disease risk.
Introduction:
This study aimed to investigate the changes in waist circumference, body composition,
and adipokine levels after the initiation of antiretroviral therapy consisting of dolutegravir, bictegravir,
and tenofovir alafenamide and evaluate the relationships between these parameters in Japanese
patients living with human immunodeficiency virus.
Methods:
This is a single-center, prospective, observational study. Waist circumference, body composition,
and adipokine levels were measured at baseline and 12 months after antiretroviral therapy
initiation in antiretroviral therapy-naive Japanese patients living with human immunodeficiency virus.
Body composition was determined by bioelectrical impedance analysis.
Results:
We included 11 patients (10 bictegravir/TAF/emtricitabine, 1 dolutegravir/lamivudine) in
this study. The results showed no significant changes in waist circumference and body composition
among the patients. The leptin/adiponectin ratio and serum leptin levels significantly increased after
antiretroviral therapy initiation. Changes in waist circumference, fat mass, and visceral fat area
showed a strong positive correlation.
Conclusion:
The leptin/adiponectin ratio increased following antiretroviral therapy initiation. The
waist circumference measurement can be a simple, inexpensive, and useful method to identify changes
in fat mass and visceral fat area after initiation of antiretroviral therapy.
Funder
Japan Society for the Promotion of Science KAKENHI
Publisher
Bentham Science Publishers Ltd.
Subject
Virology,Infectious Diseases
Cited by
1 articles.
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