Affiliation:
1. Medical Microbiology and Molecular Biology Lab. Interdisciplinary Biotechnology Unit, Aligarh Muslim University,
Aligarh 202002, India
Abstract
Abstract:
One of the greatest threats to the global world is infectious diseases. The morbidity and fatality
of infectious diseases cause 17 million deaths annually. The recent COVID-19 pandemic describes
the uncertain potential of these diseases. Understanding the pathogenesis of infectious agents, including
bacteria, viruses, fungi, etc. and the evolution of rapid diagnostic techniques and treatments has become
a pressing priority to improve infectious disease outcomes worldwide. Clustered regularly interspaced
short palindromic repeats (CRISPR) constitute the adaptive immune system of archaea and bacteria
along with CRISPR-associated (Cas) proteins that recognize and destroy foreign DNA acting as molecular
scissors. Since their discovery, CRISPR systems are classified into 6 types and 22 subtypes. Type
II, V, and VI are used for diagnostic purposes. Utilizing the CRISPR-Cas system's capabilities will aid
promote the development of novel and improved diagnostics as well as innovative delivery systems and
the prevention and treatment of infectious diseases.
Publisher
Bentham Science Publishers Ltd.
Subject
Cell Biology,Molecular Biology,Biochemistry,General Medicine
Cited by
2 articles.
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