Affiliation:
1. Shanghai Jiao Tong University School of Medicine Neurosurgery Shanghai China
2. Nanchang University Jiangxi Key Laboratory of Translational Cancer Research Nanchang China
3. Fudan University School of Public Health Shanghai China
Abstract
Abstract:
Long noncoding RNAs (lncRNAs) represent a large subgroup of RNA transcripts that
lack the function of coding proteins and may be essential universal genes involved in carcinogenesis
and metastasis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNAMALAT1)
is overexpressed in various human tumors, including gliomas. However, the biological
function and molecular mechanism of action of lncRNA-MALAT1 in gliomas have not yet been
systematically elucidated. Accumulating evidence suggests that the abnormal expression of
lncRNA-MALAT1 in gliomas is associated with various physical properties of the glioma, such as
tumor growth, metastasis, apoptosis, drug resistance, and prognosis. Furthermore, lncRNAs, as tumor
progression and prognostic markers in gliomas, may affect tumorigenesis, proliferation of glioma
stem cells, and drug resistance. In this review, we summarize the knowledge on the biological
functions and prognostic value of lncRNA-MALAT1 in gliomas. This mini-review aims to deepen
the understanding of lncRNA-MALAT1 as a novel potential therapeutic target for the individualized
precision treatment of gliomas.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
1 articles.
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