Affiliation:
1. Department of Nutrition and Dietetics, Faculty of Health Sciences, Eastern Mediterranean University, Famagusta, T.R. North Cyprus via Mersin 10 Turkey
Abstract
Background:
Maternal nutritional factors play a significant role in maternal glucose
and fatty acid transfer across the placenta and contribute to further enhancing fetal growth and
also increasing the risk of fetal macrosomia.
Objective:
This review aims to provide the effects of placental transfer of maternal fatty acids
and glucose on fetal macrosomia, and also highlights the maternal nutritional interventions to
prevent fetal adiposity.
Method:
All abstracts and full-text articles have been examined and the most relevant articles
have been included in this review.
Results:
Maternal obesity, maternal over-nutrition, and gestational diabetes can permanently influence
the risk of macrosomia via the effects of the placental transfer of maternal fatty acids and
glucose on the fetus. These conditions are associated with unfavorable maternal environments
that lead to fetal growth acceleration by adverse fetal programming outcomes and increased risk
of childhood obesity. As a result, pregnancy should be viewed as a window of opportunity for
the development of maternal nutritional therapies that improve maternal glucose and lipid metabolism,
potentially reducing macrosomia and juvenile obesity.
Conclusion:
Evidence-based techniques for managing maternal glucose and fatty acid transfer to
the fetus include maintaining maternal pre-pregnancy body mass index (BMI), acceptable weight
gain throughout pregnancy, and maternal nutritional interventions during pregnancy. Healthy
dietary patterns (such as the Mediterranean diet) and/or dietary consumption of certain nutrients
(such as omega-3 fatty acids) are among the suggestions for fetal macrosomia prevention.
Publisher
Bentham Science Publishers Ltd.
Subject
Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Food Science
Cited by
1 articles.
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