Education, APOE ε4, and Cognition in Individuals with Subjective Cognitive Decline with Worry in the SILCODE Study
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Published:2021-05
Issue:6
Volume:18
Page:492-498
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ISSN:1567-2050
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Container-title:Current Alzheimer Research
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language:en
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Short-container-title:CAR
Author:
Chen Guanqun1,
Lin Li1,
Yang Kun2,
Han Ying1
Affiliation:
1. Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
2. Department of Evidence-Based Medicine, Xuanwu Hospital of Capital Medical University, Beijing, China
Abstract
Background:
Education could offer a protective effect on cognition in individuals with
Subjective Cognitive Decline (SCD), which is considered to be the early stage of Alzheimer’s Disease
(AD). However, the effect of education on cognition in SCD individuals with SCD-plus features
is not clear.
Objective:
The aim of the study was to explore the effect of education on cognition in SCD individ-
uals with SCD-plus features.
Methods:
A total of 234 individuals with SCD were included from the Sino Longitudinal Study on
Cognitive Decline (SILCODE). Cognition was assessed across 4 domains (memory, executive, language,
and general cognitive functions). Multiple linear regression models were constructed to examine
the effect of education on cognitive scores in individuals without worry (n=91) and with worry
(n=143). Furthermore, we assessed differences in effects between APOE ε4 noncarriers and
APOE ε4 carriers in both groups.
Results:
Multiple linear regression analysis showed a positive effect of education on memory, executive,
and language cognition in individuals without worry and all cognitive domains in individuals
with worry. Furthermore, we found a positive effect of education on executive cognition in
APOE ε4 noncarriers without worry and language and general cognition in APOE ε4 carriers without
worry. Meanwhile, education had a positive effect on all cognitive domains in APOE ε4 noncarriers
with worry and executive, language, and general cognition in APOE ε4 carriers with worry.
Conclusion:
This study indicates that education has the potential to delay or reduce cognitive dec-
line in SCD individuals with SCD-plus features.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Neurology (clinical),Neurology
Cited by
1 articles.
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