Affiliation:
1. Departments of Precision Medicine, University of Campania "Luigi Vanvitelli", via Luigi De Crecchio 7, 80138 Naples, Italy
2. Experimental Medicine, University of Campania "Luigi Vanvitelli", via Luigi De Crecchio 7, 80138 Naples,
Italy
Abstract
Background:
Transglutaminase 2 is a ubiquitous multifunctional enzyme and the best studied of the transglutaminase family. Consistent with its role in promoting post-translational modifications of proteins, Transglutaminase 2 is involved in many physiological processes such as apoptosis, signal transduction, and cellular adhesion. Several findings indicate that Transglutaminase 2 plays a role in the pathological processes of various inflammation-related diseases, including neurodegenerative diseases.
Objective:
We tested the potential modulatory effects on amyloid-β–induced Transglutaminase 2 expression and activities of 2-pentadecyl-2-oxazoline, a plant-derived agent, which has shown effectiveness against chronic pain and associated neuropsychiatric disorders, both in mouse and human microglial cell lines.
Methods: We used biochemistry, molecular and cell biology techniques to evaluate the potential modulatory effects on amyloid-β – induced Transglutaminase 2 expression and activities of 2- pentadecyl-2-oxazoline in mouse and human microglial cell lines.
Results:
2-pentadecyl-2-oxazoline was able to modulate amyloid-β–induced Transglutaminase 2 expression and activities in mouse and human microglial cell lines.
Conclusion:
Transglutaminase 2 confirms its role as a neuroinflammation marker, the inhibition of which could be a potential preventive and therapeutic approach, while 2-pentadecyl-2-oxazoline is a potent modulator of the amyloid-β–induced Transglutaminase 2 expression and activities in mouse and human microglial cell lines.
Publisher
Bentham Science Publishers Ltd.
Subject
Neurology (clinical),Neurology