Affiliation:
1. Cell and Molecular Biology Department, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore -575018, Karnataka, India
Abstract
Background:
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has gained a lot
of attention because of its involvement in respiratory diseases. Interleukin-17 cytokine family includes
six members, out of which, IL-17A participates towards the immune responses in allergy and
inflammation. It also modulates the progression of respiratory disorders.
Objective:
The present review is an insight into the involvement and contributions of the proinflammatory
cytokine IL-17A in chronic respiratory diseases like Idiopathic Pulmonary Fibrosis
(IPF), Chronic Obstructive Pulmonary Distress (COPD), asthma, pneumonia, obliterative bronchiolitis,
lung cancer and many others.
Conclusion:
IL-17A is a major regulator of inflammatory responses. In all the mentioned diseases, IL-
17A plays a prime role in inducing the diseases, whereas the lack of this pro-inflammatory cytokine
reduces the severity of respective respiratory diseases. Thereby, this review suggests IL-17A as an
instrumental target in chronic respiratory diseases.
Publisher
Bentham Science Publishers Ltd.
Subject
Immunology and Allergy,Endocrinology, Diabetes and Metabolism
Cited by
13 articles.
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