Current Perspectives on Nanoparticle-based Targeted Drug Delivery Approaches in Breast Cancer Treatment

Abstract

Abstract: Breast cancer is avertible yet one of the most widespread carcinomas globally. Though periodic screening and monitoring have resulted in reduced incidences, the malignancy claims in-creased death rates across the globe. Due to the non-specific and aggressive nature of available conventional cancer therapeutics, there is a crucial need for better treatment paradigms. Recent advancements in nanotechnology have aided in this by utilizing nanocarriers in targeted drug de-livery approaches. Optimized nanoparticles have been used to enhance the circulation time and target the efficacy of conventional therapeutic drugs. Passive targeting comprises surface modula-tion to avoid drug elimination via a standard body defense system. Active targeting includes chem-ical interaction with various genes, receptors, and antigens overexpressed during cancer progres-sion. Therefore, the present review recapitulates drug delivery approaches and nanoparticle-based targeting that can potentially overcome the limitations of conventional drug therapies.