Affiliation:
1. Department of Pharmacology, University Institute of Pharma Sciences, Chandigarh University,
Mohali, Punjab, India
2. Department of Pharmacology, Maharishi Markandeswar Medical College and Hospital, Sultanpur, Khumarhati, Solan-173229,
Himachal Pradesh, India
Abstract
Abstract:
The unbearable heat waves that we are experiencing these days around the world are the
result of increasing global warming, leading to heat stress and a constant health issue for the existing
population. The thermoregulatory dysfunction of the human body due to climatological changes might
result in fluid and electrolyte imbalance and transforms the human body from a normal physiological
condition to a distorted pathological state. Subsequently, at one point in time, the human body may fail
to handle its normal thermoregulatory function in the form of sudden unconsciousness and health defects.
There might be associated dehydration that imposes renal damage, even to the extent to cause
acute kidney injury (AKI), followed by chronic kidney disease (CKD). Thus, we cannot deny CKD as
a major cause of death, mainly in patients having long-standing medical issues such as cardiac dysfunction,
hypertension, diabetes, and obesity, heat stress nephropathy (HSN) might therefore become
a major health problem. There is always a hopeful way in our hands, fortunately, which is of course
prevention, that comes through government policies and human awareness. The present review brings
out light on the alarming resultant facts of heat stress, dehydration, its pathology, molecular derangements,
and recommendations for the prevention of heat stress nephropathy.
Publisher
Bentham Science Publishers Ltd.
Subject
Immunology and Allergy,Endocrinology, Diabetes and Metabolism
Cited by
1 articles.
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1. Pathophysiologie und Management der Hitzeerkrankung;Medizinische Klinik - Intensivmedizin und Notfallmedizin;2023-10-13