The influence of lubricant on the morphology of ultra-high molecular weight polyethylene wear debris generated in laboratory tests

Abstract

Since the implication of polyethylene wear debris as a major cause of osteolysis in total joint replacements, there has been much interest in polyethylene wear studies and in cell culture studies using ultra-high molecular weight polyethylene (UHMWPE) wear debris. Studies have shown that particles in the 0.1-10 μm size range are particularly important in causing adverse cellular reactions resulting in osteolysis. The morphology, the mass and size distributions, and the number of wear particles produced at the joint surfaces are influenced by the tribological conditions at the joint. Laboratory wear tests are used to investigate the wear properties of prosthetic joint materials and different research groups have used different lubricants in these tests. This paper shows that the volumetric wear and morphology of UHMWPE particles generated in vitro are influenced by the type of lubricant used. This study compared, quantitatively, UHMWPE wear debris generated in deionized water to debris that was generated in a system lubricated by bovine serum which was diluted to 25 per cent. The wear factors of UHMWPE in water and serum lubricants were significantly different ( p<0.05). UHMWPE wore 14 times more in water than in serum. Quantitative analysis of the wear particles showed that the debris that was generated in serum was morphologically different from debris that was produced in a water-lubricated system. Furthermore, the particles produced in serum showed a closer similarity to those found in retrieved acetabular tissues.