PATHOGENETIC JUSTIFICATION OF IMMUNOCORRECTION IN PATIENTS WITH PYELONEPHRITIS DEPENDING ON THE FORM OF THE DISEASE

Abstract

Abstract. Goal. To find out the state of the cellular link of the immune system in patients with pyelonephritis, followed by the justification of the appointment of immunocorrectors. Materials and methods. Retrospectively and prospectively analyzed 236 disease histories of patients who received inpatient treatment in the center of purulent-septic surgery of KNP “City Hospital №3” in Zaporizhia for the period 2016-2022. The main group consisted of 114 patients, the comparison group - 122 patients. The results. Practically all forms of dysentery, both primary and recurrent, occur against the background of secondary immunodeficiency with varying degrees of immune disorders. Patients with erysipelas of all forms, which occur against the background of secondary immunodeficiency in the first degree of immune disorders (which is probably a transitory state), do not need correction with immunomodulators, while patients with II and III degrees, who are immunologically compromised, require mandatory the appointment of immunomodulators. Conclusions. Studies of the cellular link of the immune system in patients with dysentery contribute to the development of approaches to the appointment of pathogenetically justified immunocorrection, which allows achieving a stable remission or, at least, reducing the risk of chronicity and aggravation of the disease.