DYNAMICS OF CHANGES IN THE FUNCTIONAL ACTIVITY OF NONSPECIFIC INFLAMMATORY FACTORS IN WIDESPREAD PERITONITIS

Abstract

Summary. Aim. The determination of the impact of the developed complex treatment of patients with peritonitis on the functional state of effector cells of antimicrobial resistance during the course of the disease. Materials and methods. The study included patients with toxic and terminal stages of peritonitis (124 patients), who were treated in 2022. They were divided into 3 groups. Group I (main) included 39 (31.4 %) patients whose complex treatment included cytochrome C. Group II (main) included 41 (33.1 %) patients whose complex treatment included cytochrome C and Tivorel. The comparison group consisted of 44 (35.5 %) patients in whom the indicated drugs were not used. Results. In patients of group I, the 7th day of the study was characterized by a significant decrease in the spontaneous activity of neutrophil granulocytes (NG) in the NBT-test relative to the initial values by 2.21 times (p<0.001). However, a 2.91 (p<0.001) times increase in the activity of induced NG was determined. An increase in the functional spontaneous activity of monocytes relative to the initial values was determined by 3.12 times (p<0.001). Indicators of functional activity in the induced reaction exceeded initial values by 4.96 times (p<0.001). In patients of the II group, on the 7th day of the study, a decrease in the functional activity of NG in the spontaneous NBT-test was found relative to the initial values by 2.94 times (p<0.001). A 4.52-fold increase in NG activity in the induced test relative to baseline values was determined (p<0.001). An increase in the functional activity of monocytes was established in the spontaneous and induced NBT-test. These indicators were 2.93 (p<0.001) times and 5.25 (p<0.001) times relative to the initial values, respectively. Conclusions. The activity of neutrophil granulocytes and monocytes in the spontaneous and induced nitroblue tetrazolium recovery test (NBT-test) are objective indicators of the activity of nonspecific inflammatory factors in patients with peritonitis.