Why Do We Still Not Have Cardioprotective Drugs?

Author:

Downey James M.1,Cohen Michael V.12

Affiliation:

1. Department of Physiology, University of South Alabama, College of Medicine

2. Department of Medicine, University of South Alabama, College of Medicine

Publisher

Japanese Circulation Society

Subject

Cardiology and Cardiovascular Medicine,General Medicine

Reference54 articles.

1. 1. Braunwald E. Reduction of myocardial-infarct size [Editorial]. N Engl J Med 1974; 291: 525-526.

2. 2. Maroko PR, Kjekshus JK, Sobel BE, Watanabe T, Covell JW, Ross J Jr, et al. Factors influencing infarct size following experimental coronary artery occlusions. Circulation 1971; 43: 67-82.

3. 3. Reimer KA, Rasmussen MM, Jennings RB. Reduction by propranolol of myocardial necrosis following temporary coronary artery occlusion in dogs. Circ Res 1973; 33: 353-363.

4. 4. Reimer KA, Jennings RB. Can we really quantitate myocardial cell injury? In: Hearse DJ, Yellon DM, editors.Therapeutic approaches to myocardial infarct size limitation. Raven Press: New York; 1984; 163-184.

5. 5. Tissier R, Cohen MV, Downey JM. Protecting the acutely ischemic myocardium beyond reperfusion therapies: Are we any closer to realizing the dream of infarct size elimination? Arch Mal Coeur Vaiss 2007; 100: 794-802.

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