Clinical significance of MET alterations in non-small cell lung cancer and currently available therapies
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Published:2023-11-08
Issue:3
Volume:13
Page:37-48
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ISSN:2587-6813
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Container-title:Malignant tumours
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language:
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Short-container-title:Malignant Tumours
Author:
Smolin S. А.1, Zhukova L. G.1, Smolin А. V.2, Bubenko D. N.1, Grechukhina К. S.3
Affiliation:
1. A. S. Loginov Moscow Clinical Scientific Center 2. N. N. Burdenko Central Military Clinical Hospital 3. A. S. Loginov Moscow Clinical Scientific Center; Central State Medical Academy
Abstract
Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality both in Russia and worldwide. At diagnosis, most patients have advanced disease when the use of local treatment modalities is limited and systemic chemotherapy fails to provide a pronounced and sustained benefit. The advent of targeted therapies has significantly changed the treatment paradigm of NSCLC. Genetic alterations representing potential molecular targets have been identified in up to 60 % of non-squamous NSCLC cases, and agents directed against 50 % oncogenic targets have been approved. Various activat ing mutations of the MET signaling pathway (gene amplifications and alterations) associated with unfavorable disease outcomes occur in 2–4 % of NSCLC patients. Recently, significant advances in the development of therapies targeting this signaling pathway have been made. The article provides an overview of the key studies evaluating novel therapeutic options for NSCLC with MET alterations.
Publisher
Russian Society of Clinical Oncology
Reference42 articles.
1. Sung, H. Global Cancer Statistics 2020 : GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries / H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray // CA : a cancer journal for clinicians .– 2021 .– Vol. 71, iss. 3 .– P. 209–249. 2. Chemotherapy in Addition to Supportive Care Improves Survival in Advanced Non–Small-Cell Lung Cancer : A Systematic Review and Meta-Analysis of Individual Patient Data From 16 Randomized Controlled Trials // Journal of Clinical Oncology .– 2008 .– Vol. 26, iss. 28 .– P. 4617–4625. 3. Wang, C. The landscape of immune checkpoint inhibitor plus chemotherapy versus immunotherapy for advanced non-small-cell lung cancer : A systematic review and meta-analysis / C. Wang, W. Qiao, Y. Jiang, M. Zhu, J. Shao, T. Wang, D. Liu, W. Li // Journal of cellular physiology .– 2020 .– Vol. 235, iss. 5 .– P. 4913–4927. 4. Mok, T. S. K. Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042) : a randomised, open-label, controlled, phase 3 trial / T. S. K. Mok, Y .– L. Wu, I. Kudaba, D. M. Kowalski, B. C. Cho, H. Z. Turna, G. Castro, V. Srimuninnimit, K. K. Laktionov, I. Bondarenko, K. Kubota, G. M. Lubiniecki, J. Zhang, D. Kush, G. Lopes, G. Adamchuk, M .– J. Ahn, A. Alexandru, O. Altundag, A. Alyasova, O. Andrusenko, K. Aoe, A. Araujo, O. Aren, O. Arrieta Rodriguez, T. Ativitavas, O. Avendano, F. Barata, C. H. Barrios, C. Beato, P. Bergstrom, D. Betticher, L. Bolotina, M. Botha, S. Buddu, C. Caglevic, A. Cardona, H. Castro, F. Cay Senler, C. A. S. Cerny, A. Cesas, G .– C. Chan, J. Chang, G. Chen, X. Chen, S. Cheng, Y. Cheng, N. Cherciu, C .– H. Chiu, S. Cicenas, D. Ciurescu, G. Cohen, M. A. Costa, P. Danchaivijitr, F. de Angelis, S. J. de Azevedo, M. Dediu, T. Deliverski, P. R. M. de Marchi, F. de The Bustamante Valles, Z. Ding, B. Doganov, L. Dreosti, R. Duarte, R. Edusma-Dy, S. Emelyanov, M. Erman, Y. Fan, L. Fein, J. Feng, D. Fenton, G. Fernandes, C. Ferreira, F. A. Franke, H. Freitas, Y. Fujisaka, H. Galindo, C. Galvez, D. Ganea, N. Gil, G. Girotto, E. Goker, T. Goksel, G. Gomez Aubin, L. Gomez Wolff, H. Griph, M. Gumus, J. Hall, G. Hart, L. Havel, J. He, Y. He, C. Hernandez Hernandez, V. Hespanhol, T. Hirashima, C. M. J. Ho, A. Horiike, Y. Hosomi, K. Hotta, M. Hou, S. H. How, T .– C. Hsia, Y. Hu, M. Ichiki, F. Imamura, O. Ivashchuk, Y. Iwamoto, J. Jaal, J. Jassem, C. Jordaan, R. A. Juergens, D. Kaen, E. Kalinka-Warzocha, N. Karaseva, B. Karaszewska, A. Kazarnowicz, K. Kasahara, N. Katakami, T. Kato, T. Kawaguchi, J. H. Kim, K. Kishi, V. Kolek, M. Koleva, P. Kolman, L. Koubkova, R. Kowalyszyn, D. Kowalski, K. Koynov, D. Ksienski, T. Kurata, G. Kuusk, L. Kuzina, I. Laczo, G. E. I. Ladrera, K. Laktionov, G. Landers, S. Lazarev, G. Lerzo, K. Lesniewski Kmak, W. Li, C. K. Liam, I. Lifirenko, O. Lipatov, X. Liu, Z. Liu, S. H. Lo, V. Lopes, K. Lopez, S. Lu, G. Martinengo, L. Mas, M. Matrosova, R. Micheva, Z. Milanova, L. Miron, T. Mok, M. Molina, S. Murakami, Y. Nakahara, T. Q. Nguyen, T. Nishimura, A. Ochsenbein, T. Ohira, R. Ohman, C. K. Ong, G. Ostoros, X. Ouyang, E. Ovchinnikova, O. Ozyilkan, L. Petruzelka, X. D. Pham, P. Picon, B. Piko, A. Poltoratsky, O. Ponomarova, P. Popelkova, G. Purkalne, S. Qin, R. Ramlau, B. Rappaport, F. Rey, E. Richardet, J. Roubec, P. Ruff, A. Rusyn, H. Saka, J. Salas, M. Sandoval, L. Santos, T. Sawa, K. Seetalarom, M. Seker, N. Seki, F. Seolwane, L. Shepherd, S. Shevnya, A. K. Shimada, Y. Shparyk, I. Sinielnikov, D. Sirbu, O. Smaletz, J. P. H. Soares, A. Sookprasert, G. Speranza, V. Sriuranpong, Z. Stara, W .– C. Su, S. Suga wara, W. Szpak, K. Takahashi, N. Takigawa, H. Tanaka, J. Tan Chun Bing, Q. Tang, P. Taranov, H. Tejada, L. M. Tho, Y. Torii, D. Trukhyn, M. Turdean, H. Turna, G. Ursol, J. Vanasek, M. Varela, M. Vallejo, L. Vera, A .– P. Victorino, T. Vlasek, I. Vynnychenko, B. Wang, J. Wang, K. Wang, Y. Wu, K. Yamada, C .– H. Yang, T. Yokoyama, T. Yokoyama, H. Yoshioka, F. Yumuk, A. Zambrano, J. J. Zarba, O. Zarubenkov, M. Zemaitis, L. Zhang, X. Zhang, J. Zhao, C. Zhou, J. Zhou, Q. Zhou, A. Zippelius // The Lancet .– 2019 .– Vol. 393, iss. 10183 .– P. 1819–1830. 5. Seegobin, K. Immunotherapy in Non-Small Cell Lung Cancer With Actionable Mutations Other Than EGFR / K. Seegobin, U. Majeed, N. Wiest, R. Manochakian, Y. Lou, Y. Zhao // Frontiers in oncology .– 2021 .– Vol. 11 .– P. 750657.
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