Pre-emptive analgesia and its supraspinal mechanisms: enhanced descending inhibition and decreased descending facilitation by dexmedetomidine

Author:

You Hao-Jun1,Lei Jing1,Xiao Ying12,Ye Gang3,Sun Zhi-Hong4,Yang Lan1,Niu Nan1

Affiliation:

1. Center for Biomedical Research on Pain (CBRP), College of Medicine; Xi'an Jiaotong University; Xi'an 710061 PR China

2. Department of Anesthesia; First affiliated hospital of Xi'an Jiaotong University; Xi'an 710061 PR China

3. Department of Pain; Tongji Hospital affiliated to Shanghai Tongji University; Shanghai 200065 PR China

4. College of Life Science; Yan'an University; Yan'an 716000 PR China

Publisher

Wiley

Subject

Physiology

Reference43 articles.

1. Endogenous pain control mechanisms: review and hypothesis;Basbaum;Ann Neurol,1978

2. The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation;Basbaum;J Comp Neurol,1979

3. The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat;Belcher;Brain Res,1978

4. Peripheral and spinal mechanisms of nociception;Besson;Physiol Rev,1987

5. Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat;Bol;J Pharmacol Exp Ther,1997

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