RAS at 40: Update from the RAS Initiative-Reference-Cited by-同舟云学术

RAS at 40: Update from the RAS Initiative

Published:2022-01-19 Issue:4 Volume:12 Page:895-898
ISSN:2159-8274
Container-title:Cancer Discovery
language:en
Short-container-title:

Author:

Nissley Dwight V.¹,McCormick Frank²^ORCID

Affiliation:

1. 1Frederick National Laboratory for Cancer Research, Frederick, Maryland.

2. 2University of California, San Francisco, San Francisco, California.

Abstract

Summary: The RAS Initiative was launched in 2013 to address unmet clinical needs of patients with KRAS-driven cancers. The Initiative is based at Frederick National Laboratory for Cancer Research in Frederick, MD, and involves multiple collaborations with the RAS research community in academia and industry with the shared goal of developing RAS therapies.

Funder

NCI NIH

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology

Link

https://aacrjournals.org/cancerdiscovery/article-pdf/12/4/895/3108005/895.pdf

Reference8 articles.

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2. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation;Sun;Angew Chem Int Ed Engl,2012

3. Structural basis of recognition of farnesylated and methylated KRAS4b by PDEdelta;Dharmaiah;Proc Natl Acad Sci U S A,2016