Affiliation:
1. 1Nuclear Function Group, German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association, Bonn, Germany.
Abstract
Summary:The study by Bercier and colleagues investigates the mechanisms of action of arsenic trioxide (ATO). The authors find that ATO promotes transition of PML nuclear bodies to a gel-like state via the PML trimerization domain and a critical cysteine residue. Overall, this work sheds new light onto how PML–RARα, the oncogene of APL, is targeted by ATO for disease eradication.See related article by Bercier et al., p. 2548 (6).
Publisher
American Association for Cancer Research (AACR)
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