Affiliation:
1. 1West China Hospital of Sichuan University, Chengdu, China;
2. 2Affiliated Hospital of Chengdu University, Chengdu, China;
3. 3Chengdu University of Traditional Chinese Medicine, Chengdu, China;
4. 4Thomas Jefferson University, Philadelphia, PA.
Abstract
Abstract
Background: Malnutrition is a severe but modifiable risk factor for cancers. However, the relationship between malnutrition and the survival of patients with brain metastases has not been fully revealed. We aimed to evaluate the prevalence of malnutrition and assess its prognostic value on patients with brain metastases.
Method: We retrospectively recruited 2633 patients with brain metastases between January 2014 and September 2020. Three malnutrition scores were used to evaluate patients' malnutrition status at their first admission, including controlling nutritional status (CONUT), the nutritional risk index (NRI), and the prognostic nutritional index (PNI). The association between malnutrition and overall survival was estimated.
Results: A total of 1984 (75.4%) of patients were assessed as any degree malnourished and 963 (36.6%) of patients were assessed as moderate to severe malnutrition by at least one malnutrition score. The three malnutrition scores were associated with each other and with BMI. Malnutrition assessed by any of the three scores was significantly associated with poor overall survival (adjust hazard ratio [HR] and 95% confidence interval [CI] for CONUT: 1.12 [1.10-1.16]; for NRI: 0.97 [0.97-0.98]; for PNI: 0.96 [0.95-0.97], all p values <0.001). Furthermore, malnutrition was a better indicator than BMI, and adding malnutrition to the Graded Prognostic Assessment scoring system could significantly improve the accuracy of prognosis prediction.
Conclusion: Malnutrition was prevalent in patients with brain metastases and was significantly associated with overall survival. Malnutrition monitoring on patients' first admission could improve the survival prediction ability for brain metastasis.
Citation Format: Zheran Liu, Yu Zhang, Yiyan Pei, Yan He, Jiayi Yu, Renjie Zhang, Jingjing Wang, Weelic Chong, Yang Hai, Xingchen Peng, Fang Fang. Prevalence and prognostic significance of malnutrition in patients with brain metastasis. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5562.
Publisher
American Association for Cancer Research (AACR)